| 货号 | 10008520-1mg |
| 描述 | 4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker.1 Tolbutamide 4-hydroxylation is an often used probe reaction in the pharmaceutical industry for the characterization of CYP2C8 and CYP2C9 involvement in the metabolism of clinical drugs.2,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hansen, L.L., and Brosen, K. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Therapeutic Drug Monitoring 21, 664-671 (1999). 2.Yuan, R.,Madani, S.,Wei, X.-X., et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab. Dispos. 30(12), 1311-1319 (2002). 3.Miners, J.O., and Birkett, D.J. Use of tolbutamide as a substrate probe for human heptic cytochrome P450 2C9. Methods in Enzymology 272, 139-145 (1996). 4.Testino, S.A., Jr., and Patonay, G. High-throughput inhibition screening of major human cytochrome p450 enzymes using in vitro cocktail and liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical & Biomedical Analysis 30, 1459-1467 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 286.4 |
| 分子式 | C12H18N2O4S |
| CAS号 | 5719-85-7 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |