| 货号 | 10007945-5mg |
| 描述 | D-erythro-Sphinganine is a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins,1,2 as well as in some cancers.3 Sphinganine can block protein kinase C activation in some cases but not others.4,5 Sphinganine-1-phosphate can emulate sphingosine-1-phosphate in cell signaling or have opposite intracellular effects.6,7,8 |
| 别名 | D-erythro-Dihydrosphingosine;Dihydro-D-erythroSphingosine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pruett, S.T.,Bushnev, A.,Hagedorn, K., et al. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. Journal of Lipid Research 49, 1621-1639 (2008). 2.Shephard, G.S.,van der Westhuizen, L., and Sewram, V. Biomarkers of exposure to fumonisin mycotoxins: A review. Food Additives and Contaminants 24(10), 1196-1201 (2007). 3.Yin, J.,Miyazaki, K.,Shaner, R.L., et al. Altered sphingolipid metabolism induced by tumor hypoxia - new vistas in glycolipid tumor markers. FEBS Letters 584, 1872-1878 (2010). 4.Merrill, A.H., Jr.,Sereni, A.M.,Stevens, V.L., et al. Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. The Journal of Biological Chemisty 261(27), 12610-12615 (1986). 5.Merrill, A.H., Jr.,Nimkar, S.,Menaldino, D., et al. Structural requirements for long-chain (shingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry 28, 3138-3145 (1989). 6.Coste, O.,Brenneis, C.,Linke, B., et al. Sphingosine 1-phosphate modulates spinal nociceptive processing. The Journal of Biological Chemisty 283(47), 32442-32451 (2008). 7.Bu, S.,Yamanaka, M.,Pei, H., et al. Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. The FASEB Journal 20(1), 184-186 (2006). 8.Bu, S.,Kapanadze, B.,Hsu, T., et al. Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-β/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway. The Journal of Biological Chemisty 283(28), 19593-19602 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 301.5 |
| 分子式 | C18H39NO2 |
| CAS号 | 764-22-7 |
| 稳定性 | ≥ 2 years |
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