| 货号 | 10007171-5mg |
| 描述 | The fibrate class of hypolipidemic drugs such as clofibrate and fenofibrate elicit their effects by binding to and activating peroxisome proliferator-activated receptor α (PPARα). Cetaben is a unique, peroxisome proliferator-activated receptor α (PPARα)-independent peroxisome proliferator with hypolipidemic activity, characterized by reduction in serum triglyceride and cholesterol concentrations in rats.1 In male wistar rats, cetaben increased the activity of all peroxisomal enzymes examined in liver and kidney, whereas clofibrate showed a varied regulatory pattern.2 In addition to its effects on peroxisomes, cetaben inhibits cholesterol synthesis in the human hepatoma HepG2 cells resulting in reversible changes in Golgi morphology.3,4 It also blocked triglyceride synthesis by 99% and reduced cholesterol ester synthesis by >70% at a concentration of 50 µM in these same cells.4 |
| 别名 | Hexadecylamino-p-amino Benzoic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chandoga, J.,Hampl, L.,Turecky, L., et al. Cetaben is an exceptional type of peroxisome proliferator. International Journal of Biochemistry 26(5), 679-696 (1994). 2.Chandoga, J.,Rojeková, I.,Hampl, L., et al. Cetaben and fibrates both influence the activities of peroxisomal enzymes in different ways. Biochemical Pharmacology 47(3), 515-519 (1994). 3.Kovacs, W.,Walter, I., and Stangl, H. Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1 rat hepatoma and HepG2 human hepatoblastoma cells. Histochemistry and Cell Biology 115, 509-519 (2001). 4.Kovacs, W.,Schrader, M.,Walter, I., et al. The hypolipidemic compound cetaben induces changes in Golgi morphology and vesicle movement. Histochemistry and Cell Biology 122, 95-109 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 361.6 |
| 分子式 | C23H39NO2 |
| CAS号 | 55986-43-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |