| 货号 | 16257-1mg |
| 描述 | ICG-001 is a small molecule inhibitor of β-catenin/cyclic AMP responsive element binding protein binding protein (CBP)-mediated transcription (IC50 = 3 µM).1 By binding CBP, thus blocking interaction with β-catenin, it selectively induces apoptosis in transformed colon cells but not in normal cells and prevents the growth of colon carcinoma cells at 25 µM in vitro.1,2 ICG-001 has been used to specifically disrupt the β-catenin pathway in studying epithelial-mesenchymal transition during pulmonary fibrosis.3,4 Additionally, ICG-001 disruption of Wnt/β-catenin signaling has been studied in the context of regulating cancer stem cells.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Emami, K.H.,Nguyen, C.,Ma, H., et al. A small molecule inhibitor of β-catenin/CREB-binding protein transcription. Proceedings of the National Academy of Sciences of the United States of America 101(34), 12682-12687 (2004). 2.de Sousa, E.M.F.,Vermeulen, L.,Richel, D., et al. Targeting Wnt signaling in colon cancer stem cells. Clinical Cancer Research 17(4), 647-653 (2011). 3.Zhou, B.,Liu, Y.,Kahn, M., et al. Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). The Journal of Biological Chemisty 287(10), 7026-7038 (2012). 4.Henderson, W.R., Jr.,Chi, E.Y.,Ye, X., et al. Inhibition of Wnt/β-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proceedings of the National Academy of Sciences of the United States of America 107(32), 14309-14314 (2010). 5.Takahashi-Yanaga, F. and Kahn, M. Targeting Wnt signaling: Can we safely eradicate cancer stem cells? Clinical Cancer Research 16(12), 3153-3162 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 548.6 |
| 分子式 | C33H32N4O4 |
| CAS号 | 847591-62-2 |
| 稳定性 | ≥ 2 years |
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