UNC1999
货号：
14621-1mg 基本售价：
392.0 元 规格：
1 mg
产品信息
概述| 货号 | 14621-1mg |
| 描述 | The histone H3 lysine 27 (H3K27) methyltransferase EZH2 plays an important role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer.1 UNC1999 is a cell-permeable EZH2 inhibitor (IC50 = 2 nM) that is 22-fold selective over EZH1 and >1,000-fold selective over other histone methytranferases.2 UNC1999 has been shown to inhibit H3K27 methylation in MCF10A cells with an IC50 value of 124 nM.2 See the Structural Genomics Consortium (SGC) website for more information. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Simon, J.A. and Lange, C.A. Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutation Research 647, 21-29 (2008).
2.Konze, K.D.,Ma, A.,Li, F., et al. An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1. ACS Chemical Biology 8, 1324-1334 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 569.8 |
| 分子式 | C33H43N7O2 |
| CAS号 | 1431612-23-5 |
| 稳定性 | ≥ 2 years |
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