| 货号 | 10572-1mg |
| 描述 | Scriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems.1 It induces cell cycle arrest in colon cancer cells in culture and inhibits tumor growth in vitroandin vivo.2,3 Scriptaid also facilitates the cloning of inbred mouse strains produced by somatic cell nuclear transfer.4 |
| 别名 | GCK 1026; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Su, G.H.,Sohn, T.A.,Ryu, B., et al. A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. Cancer Research 60, 3137-3142 (2000). 2.Keen, J.C.,Yan, L.,Mack, K.M., et al. A novel histone deacetylase inhibitor, Scriptaid, enhances expression of functional estrogen receptor α (ER) in ER negative human breast cancer cells in combination with 5-aza 2-deoxycytidine. Breast Cancer Research and Treatment 81, 177-186 (2003). 3.Lee, E.J.,Lee, B.B.,Kim, S.J., et al. Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. International Journal of Oncology 33, 767-776 (2008). 4.Van Thuan, N.,Bui, H.T.,Kim, J.H., et al. The histone deacetylase inhibitor scriptaid enhances nascent mRNA production and rescues full-term development in cloned inbred mice. Reproduction 138, 309-317 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 326.4 |
| 分子式 | C18H18N2O4 |
| CAS号 | 287383-59-9 |
| 稳定性 | ≥ 2 years |
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