Reversin 121
货号：
18603-500ug 基本售价：
378.0 元 规格：
500 ug
产品信息
概述| 货号 | 18603-500ug |
| 描述 | Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. It binds to the P-glycoprotein multidrug transporter (MDR1) with a Kd value of 77 nM.1,2 Reversin 121 modulates P-glycoprotein ATPase activity in Sf9 insect cell membranes expressing human MDR1, plasma membrane vesicles from multidrug-resistant cells, and reconstituted proteoliposomes as well as in a variety of MDR1-expressing intact tumor cells.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sharom, F.J.,Yu, X.,Lu, P., et al. Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells. Biochemical Pharmacology 58(4), 571-586 (1999).
2.Kwak, E.L.,Sordella, R.,Bell, D.W., et al. Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proceedings of the National Academy of Sciences of the United States of America 102(21), 7665-7670 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 641.8 |
| 分子式 | C34H47N3O9 |
| CAS号 | 174630-04-7 |
| 稳定性 | ≥ 2 years |
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