TUG-891
货号：
17035-1mg 基本售价：
378.0 元 规格：
1 mg
产品信息
概述| 货号 | 17035-1mg |
| 描述 | GPR120 (free fatty acid receptor 4; FFAR4) is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.1,2 ω-3 Fatty acids, such as docosahexaenoic acid (Item No. 90310) and eicosapentaenoic acid (Item No. 90110), initiate GPR120 signaling resulting in inhibition of toll-like receptor and TNF-α inflammatory signaling pathways in a β-arrestin2/TAB1 dependent manner.2 TUG-891 is a potent and selective agonist of GPR120 with pEC50 values of 7.36 and 7.77 for human and mouse GPR120, respectively. It activates GPR40 (FFAR1) with a pEC50 value of 4.19 and shows no activity at GPR41 (FFAR3) or GPR43 (FFAR2).3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Davenport, A.P.,Alexander, S.P.H.,Sharman, J.L., et al. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: Recommendations for new pairings with cognate ligands. Pharmacological Reviews 65(3), 967-986 (2013).
2.Oh, D.Y.,Talukdar, S.,Bae, E.J., et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin sensitizing effects. Cell 142(5), 687-698 (2010).
3.Shimpukade, B.,Hudson, B.D.,Hovgaard, C.K., et al. Discovery of a potent and selective GPR120 agonist. J.Med.Chem 55, 4511-4515 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 364.4 |
| 分子式 | C23H21FO3 |
| CAS号 | 1374516-07-0 |
| 稳定性 | ≥ 2 years |
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