GN25
货号：
10948-5mg 基本售价：
378.0 元 规格：
5 mg
产品信息
概述| 货号 | 10948-5mg |
| 描述 | The tumor suppressor gene, p53, is often mutated or suppressed in human cancers. Oncogenic K-Ras has been shown to inhibit p53 function by inducing Snail to bind and eliminate p53 through exocytosis. GN25 is a 2-thio-dimethoxy naphthoquinone analog that blocks Snail binding to p53 and induces p53 expression in cancer cells in a K-Ras dependent manner. At 10 μM, GN25 significantly reduces cell proliferation in K-Ras mutated A549 and HCT116 cell lines but not in wild type MKN-45 cells. In a xenograft mouse model, 10 mg/kg GN25 yields antitumoral effects by notably reducing tumor size and progression.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lee, S.H.,Shen, G.N.,Jung, Y.S., et al. Antitumor effect of novel small chemical inhibitors of Snail-p53 binding in K-Ras-mutated cancer cells. Oncogene 29(32), 4576-4587 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 322.3 |
| 分子式 | C15H14O6S |
| CAS号 | 1227401-27-5 |
| 稳定性 | ≥ 2 years |
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