| 货号 | 10011490-25ug |
| 描述 | Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 = 4 nM).1,2,3 It is a very weak inhibitor of PP2B (IC50 > 2 μM) and does not inhibit PP2C or other phosphatases.1,3 Presumably through these actions, okadaic acid is a potent carcinogen and induces tau phosphorylation.4,5 In sponge, okadaic acid plays a role in defense, inducing apoptosis in symbiotic or parasitic annelids.6 |
| 别名 | Acanthifolicin;35-demethyl DTX1;NSC 677083;OA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bialojan, C. and Takai, A. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics. Biochemistry Journal 256, 283-290 (1988). 2.Gupta, V.,Ogawa, A.K.,Du, X., et al. A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A. Journal of Medicinal Chemistry 40, 3199-3206 (1997). 3.McCluskey, A.,Sim, A.T.R. and Sakoff, J.A. Serine-threonine protein phosphatase inhibitors: Development of potential therapeutic strategies. Journal of Medicinal Chemistry 45(6), 1151-1175 (2002). 4.Suganuma, M.,Fujiki, H.,Suguri, H., et al. Okadaic acid: An additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter. Proceedings of the National Academy of Sciences of the United States of America 85, 1768-1771 (1988). 5.Zhang, Z. and Simpkins, J.W. Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner. Brain Research 1345, 176-181 (2010). 6.Schröder, H.C.,Breter, H.J.,Fattorusso, E., et al. Okadaic acid, an apoptogenic toxin for symbiotic/parasitic annelids in the demosponge Suberites domuncula. Applied and Environmental Microbiology 72(7), 4907-4916 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 805 |
| 分子式 | C44H68O13 |
| CAS号 | 78111-17-8 |
| 稳定性 | ≥ 2 years |
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