CAY10502
货号：
10008657-500ug 基本售价：
378.0 元 规格：
500 ug
产品信息
概述| 货号 | 10008657-500ug |
| 描述 | Phospholipase A2(PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2(cPLA2α) is a 85 kDa enzyme that plays a key role in the arachidonic cascade and the inflammatory response associated with this metabolic pathway.1 CAY10502 is a potent inhibitor of calcium-dependent cytosolic PLA2α (cPLA2α) with an IC50 value of 4.3 nM for the purified enzyme from human platelets.2 It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schaloske, R.H., and Dennis, E.A. The phospholipase A2 superfamily and its group numbering system. Biochemica et Biophysica Acta 1761, 1246-1259 (2006).
2.Ludwig, J.,Bovens, S.,Brauch, C., et al. Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2α. Journal of Medicinal Chemistry 49, 2611-2620 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 523.6 |
| 分子式 | C30H37NO7 |
| CAS号 | 888320-29-4 |
| 稳定性 | ≥ 2 years |
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