| 货号 | 9807S |
| 供应商 | CST |
| 背景 | Paclitaxel belongs to the taxane family of antitumor and antileukemic agents (3). By binding to β-tubulin and promoting the assembly of microtubules, paclitaxel prevents microtubual depolymerization and blocks normal cell division (1-3). The microtubule dysfunction induced by paclitaxel results in aberrant cell mitosis and sometimes apoptosis. The IC50 of paclitaxel-induced mitotic block is 4 nM (4).紫杉醇属于抗肿瘤和抗白血病药物紫杉烷家族(3)。通过结合β-微管蛋白和促进微管装配，紫杉醇可以防止微管解聚，并阻止正常细胞分裂(1-3)。紫杉醇引起的微管功能障碍能够导致异常的细胞有丝分裂和偶发的凋亡。紫杉醇诱导有丝分裂阻遏的IC50是4nM (4)。 |
| 存放说明 | -20C |
| 参考文献 | Rowinsky, E.K. et al. (1990) J. Natl. Cancer Inst. 82, 1247-1259. Jordan, A. et al. (1998) Med. Res. Rev. 18, 259-296. Abal, M. et al. (2003) Curr. Cancer Drug Targets 3, 193-203. Long, B.H. and Fairchild, C.R. (1994) Cancer Res. 54, 4355-4361. |
Structure of PaclitaxelPaclitaxel的结构 | |
Western blot analysis of extracts from HT29 cells, either untreated or treated with indicated concentration of paclitaxel using Phospho-Cdc25C (Thr48) Antibody #9527 (upper) or control Cdc25C (5H9) Rabbit mAb Antibody #4688 (lower).Western blot 方法检测HT-29细胞提取物，分非处理组和 paclitaxel 不同浓度处理组，使用的抗体为Phospho-Cdc25C (Thr48) Antibody #9527 (上图) 或 control Cdc25C (5H9) Rabbit mAb Antibody #4688 (下图)。 |
