| 货号 | 17870-1mg |
| 描述 | Fluorescent molecular rotors are molecules whose fluorescence is inversely proportional to its intramolecular rotation.1 The intramolecular rotation of these probes, and hence their fluorescence, depends on the immediate microenvironment of the probe.1 As a result, fluorescent molecular rotors are used to evaluate changes in solution and membrane viscosity, polymerization or aggregation processes, and protein (un)folding.2,3,4 CCVJ is a fluorescent molecular rotor characterized by low background fluorescence, low fluorescence anisotropy, and good water solubility.1,4,5,6 Moreover, CCVJ has large hydrophobic structures, allowing it to associate in a non-covalent manner with hydrophobic pockets in proteins in solution.1 CCVJ is broadly used to monitor changes in solution and molecular characteristics.1,4,5 |
| 别名 | 9-(2-Carboxy-2-cyanovinyl)julolidine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Haidekker, M.A.,Nipper, M.,Mustafic, A., et al. Dyes with segmental mobility: Molecular rotors. Advanced Fluorescence Reporters in Chemistry and Biology I: Fundamentals and Molecular Design 267-308 (2010). 2.Haidekker, M.A.,Ling, T.,Angolo, M., et al. New fluorescent probes for the measurement of cell membrane viscosity. Chemistry & Biology 8(2), 123-131 (2001). 3.Iio, T.,Itakura, M.,Takahashi, S., et al. 9-(Dicyanovinyl)julolidine binding to bovine brain calmodulin. Journal of Biochemistry 109(4), 499-502 (1991). 4.Hawe, A.,Filipe, V. and Jiskoot, W. Fluorescent molecular rotors as dyes to characterize polysorbate-containing IgG formulations. Pharmaceutical Research 27(2), 314-326 (2010). 5.Ablinger, E.,Leitgeb, S. and Zimmer, A. Differential scanning fluorescence approach using a fluorescent molecular rotor to detect thermostability of proteins in surfactant-containing formulations. International Journal of Pharmacy 441, 255-260 (2013). 6.Levitt, J.A.,Chung, P.H.,Kuimova, M.K., et al. Fluorescence anisotropy of molecular rotors. Chemphyschem. 12, 662-672 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 268.3 |
| 分子式 | C16H16N2O2 |
| CAS号 | 142978-18-5 |
| 稳定性 | ≥ 2 years |
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