| 货号 | 15364-1mg |
| 描述 | Colcemid is a colchicine (Item No. 9000760) derivative that inhibits tubulin polymerization as potently as colchicine (IC50 = 2.1 and 2.4 μM, respectively) but is less toxic.1,2,3 At very low (nanomolar) concentrations, colcemid suppresses microtubule dynamicity and inhibits cell migration, while at micromolar levels it blocks microtubule assembly, arresting cells in metaphase.3,4,5 Mitotic block by colcemid is used to synchronize cells and for karyotyping in cytogenetic studies.4,6 Prolonged exposure to colcemid can activate p53, leading to apoptosis.7 |
| 别名 | Demecolcine;NSC 3096; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Muzaffar, A.,Brossi, A.,Lin, C.M., et al. Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. Journal of Medicinal Chemistry 33(2), 567-571 (1990). 2.Rieder, C.L. and Palazzo, R.E. Colcemid and the mitotic cycle. Journal of Cell Science 102(3), 387-392 (1992). 3.Jordan, M.A. and Wilson, L. Microtubules as a target for anticancer drugs. Nature Reviews.Cancer 4(4), 253-265 (2004). 4.Curlej, J.,Bulla, J. and Chrenek, P. Occurrence of chromosomal aneuploidy in rabbit oocytes and embryos at different developmental stages. Zygote 18(3), 203-207 (2010). 5.Yang, H.,Ganguly, A. and Cabral, F. Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugs. The Journal of Biological Chemisty 285(42), 32242-32250 (2010). 6.Bayani, J. and Squire, J.A. Preparation of cytogenetic specimens from tissue samples. Current Protocols in Cell Biology 22(22.2), 1-15 (2004). 7.Sablina, A.A.,Chumakov, P.M.,Levine, A.J., et al. p53 activation in response to microtubule disruption is mediated by integrin-Erk signaling. Oncogene 20(8), 899-909 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 371.4 |
| 分子式 | C21H25NO5 |
| CAS号 | 477-30-5 |
| 稳定性 | ≥ 2 years |
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