| 货号 | 14438-5mg |
| 描述 | The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis.1 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50 = 0.39 μM).2 It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death.3,4,5 This compound can be used with cells in culture and in animals.4,6,7 |
| 别名 | 1,5-Dihydroxyisoquinoline;NSC 65585; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Davar, D.,Beumer, J.H.,Hamieh, L., et al. Role of PARP inhibitors in cancer biology and therapy. Current Medicinal Chemistry 19(23), 3907-3921 (2012). 2.Banasik, M.,Komura, H.,Shimoyama, M., et al. Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. The Journal of Biological Chemisty 267(3), 1569-1575 (1992). 3.Ruscetti, T.,Lehnert, B.E.,Halbrook, J., et al. Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase. The Journal of Biological Chemisty 273(23), 14461-14467 (1998). 4.Chatterjee, P.K.,Zacharowski, K.,Cuzzocrea, S., et al. Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo. The FASEB Journal 14(5), 641-651 (2000). 5.Bowes, J.,McDonald, M.C.,Piper, J., et al. Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress. Cardiovascular Research 41(1), 126-134 (1999). 6.Byun, J.Y.,Kim, M.J.,Eum, D.Y., et al. Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells. Molecular Pharmacology 76(4), 734-744 (2009). 7.Kang, Y.H.,Yi, M.J.,Kim, M.J., et al. Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: Reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria. Cancer Research 64(24), 8960-8967 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 161.2 |
| 分子式 | C9H7NO2 |
| CAS号 | 1188540 |
| 稳定性 | ≥ 2 years |
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