Paprotrain
货号：
10524-1mg 基本售价：
375.0 元 规格：
1 mg
产品信息
概述| 货号 | 10524-1mg |
| 描述 | Mitotic kinesin-like protein 2 (MKLP-2) is an N-terminal motor from the kinesin-6 family that is essential for normal cleavage furrow ingression and cytokinesis. Its activity mediates the relocation of the chromosome passenger proteins Aurora B kinase and survivin from the centromeres to the central spindle in anaphase cells in order to facilitate cytokinesis, avoiding the generation of binucleated cells.1 Paprotrain, PAssenger PROteins TRAnsport INhibitor, is the first known inhibitor of MKLP-2. It is a cell-permeable, reversible inhibitor uncompetitive with ATP (Ki = 3.4 μM) and noncompetitive with microtubules (Ki = 1.6 μM), demonstrating ATPase inhibition of basal and microtubule-stimulated activities with IC50 values of 1.35 and 0.83 μM, respectively.2 Paprotrain does not inhibit twelve additional kinesins, including the closely related kinesin-6 motors MKLP-1 and MPP1.2 Incubation with 10-50 μM paprotrain results in binucleated cells, perturbing relocation of Aurora B kinase and survivin without affecting microtubule polymerization.2 |
| 别名 | Passenger Proteins Transport Inhibitor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Good, J.A.D.,Skoufias, D.A. and Kozielski, F. Elucidating the functionality of kinesins: An overview of small molecule inhibitors. Seminars in Cell & Developmental Biology 22(9), 935-945 (2011).
2.Tcherniuk, S.,Skoufias, D.A.,Labriere, C., et al. Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Angewandte Chemie International Edition 49, 8228-8231 (2010).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 245.3 |
| 分子式 | C16H11N3 |
| CAS号 | 57046-73-8 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
