| 货号 | 70240-1000mg |
| 描述 | Tacrine is a derivative of aminoacridine which functions as an inhibitor of both AChE and butyrylcholinesterase.1 It has been used clinically in the treatment of Alzheimer’s disease.2,3 Tacrine also inhibits the uptake of serotonin and noradrenaline in rat cerebral cortex2,4 and decreases depolarization-induced calcium influx through L-type calcium channels in SN56 neuronal cells.5 |
| 别名 | Cognex;Romotal; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Crismon, M.L. Pharmacokinetics and drug interactions of cholinesterase inhibitors administered in Alzheimer’s disease. Pharmacotherapy 18, 47-54 (1998). 2.Drukarch, B.,Leysen, J.E., and Stoof, J.C. Further analysis of the neuropharmacological profile of 9-amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer’s disease. Life Sciences 42, 1011-1017 (1988). 3.Giacobini, E. Cholinesterase inhibitors for Alzheimer’s disease therapy: From tacrine to future applications. Neurochemistry International 32, 413-419 (1998). 4.McKenna, M.T.,Proctor, G.R.,Young, L.C., et al. Novel tacrine analogues for potential use against Alzheimer’s disease: Potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors. Journal of Medicinal Chemistry 40, 3516-3523 (1997). 5.Dolezal, V.,Lisá, V., and Tucek, S. Effect of tacrine on intracellular calcium in cholinergic SN56 neuronal cells. Brain Research 769, 219-224 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 234.7 |
| 分子式 | C13H14N2 • HCl |
| CAS号 | 1684-40-8 |
| 稳定性 | ≥ 1 year |
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