ML-291
货号：
19831-1mg 基本售价：
364.0 元 规格：
1 mg
产品信息
概述| 货号 | 19831-1mg |
| 描述 | ML-291 is a novel activator of the apoptotic arm of the unfolded protein response (UPR), but not the adaptive arm.1 Specifically, it activates signaling through PERK/eIF2α/CHOP (EC50 = 762 nM) but not through IRE1/XBP1 (IC50 > 80 µM).1 ML-291 induces apoptosis in mouse embryonic fibroblasts overexpressing CHOP (EC50 ~4.8 µM), but not in wild-type or CHOP knockout cells.1 It has minimal activity against a panel of 67 receptors, ion channels, and transporters, with the exception of the dopamine transporter (68% inhibition). ML-291 displays greater than average antitumor cell cytotoxicity against colon, melanoma, and renal cancer cell lines in an NCI-60 panel.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Flaherty, D.P.,Golden, J.E.,Liu, C., et al. Selective small molecule activator of the apoptotic arm of the UPR. Probe Reports from the NIH Molecular Libraries Program (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 413.8 |
| 分子式 | C16H16ClN3O6S |
| CAS号 | 1523437-16-2 |
| 稳定性 | ≥ 2 years |
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