SR9238
货号：
18771-1mg 基本售价：
364.0 元 规格：
1 mg
产品信息
概述| 货号 | 18771-1mg |
| 描述 | The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors.1 They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9238 is an inverse agonist of the two LXR isoforms, LXRα and LXRβ (IC50s = 214 and 43 nM, respectively).2 It displays liver specificity in vivo, with little action at peripheral LXR. SR9238 suppresses hepatic lipogenesis, inflammation, lipid accumulation, and fibrosis in mouse models of non-alcoholic steatohepatitis.2,3 It also reduces plasma cholesterol levels in diet-induced obese mice.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gabbi, C.,Warner, M., and Gustafsson, J.Ä. Action mechanisms of liver X receptors. Biochemical and Biophysical Research Communications 446(3), 647-650 (2014).
2.Griffett, K.,Solt, L.A.,El-Dien, B., et al. A liver-selective LXR inverse agonist that suppresses hepatic steatosis. ACS Chemical Biology 8(3), 559-567 (2013).
3.Griffett, K.,Welch, R.D.,Flaveny, C.A., et al. The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis. Mol.Metab. 4(4), 353-357 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 595.7 |
| 分子式 | C31H33NO7S2 |
| CAS号 | 1416153-62-2 |
| 稳定性 | ≥ 2 years |
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