A-66
货号：
17382-1mg 基本售价：
364.0 元 规格：
1 mg
产品信息
概述| 货号 | 17382-1mg |
| 描述 | A-66 is a potent, selective inhibitor of the PI3K isoform p110α (IC50 = 32 nM in a cell-free assay).1 It displays over 100-fold selectivity for p110α over other isoforms. A-66 is effective in vivo, suppressing the growth of SK-OV-3 tumor xenografts in mice.1 It also impairs all measures of in vivo insulin action in mice.2 A-66 partially suppresses B cell receptor-dependent Akt activation and proliferation.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jamieson, S.,Flanagan, J.U.,Kolekar, S., et al. A drug targeting only p110a can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem. J. 438, 53-62 (2011).
2.Smith, G.C.,Ong, W.K.,Rewcastle, G.W., et al. Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo. Biochem. J. 442, 161-169 (2012).
3.So, L.,Yea, S.S.,Oak, J.S., et al. Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function. The Journal of Biological Chemisty 288(8), 5718-5731 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 393.5 |
| 分子式 | C17H23N5O2S2 |
| CAS号 | 1166227-08-2 |
| 稳定性 | ≥ 2 years |
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