| 货号 | 16719-500ug |
| 描述 | Amastatin is a slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of human serum AP-A (glutamyl AP; IC50 = 0.54 µg/ml) but not of AP-B (arginine AP).1,2 It also inhibits AP-N (AP-M, alanyl AP; Ki = 20-200 nM), leucyl-cystinyl AP (Ki = 20-220 nM), and endoplasmic reticulum AP 1 (Ki = 41.8 µM).3,4,5,6 Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin, or thermolysin.1 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Aoyagi, T.,Tobe, H.,Kojima, F., et al. Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes. J.Antibiot.(Tokyo) 31(6), 636-638 (1978). 2.Wilkes, S.H. and Prescott, J.M. The slow, tight binding of bestatin and amastatin to aminopeptidases. The Journal of Biological Chemisty 260(24), 13154-13162 (1985). 3.Rich, D.H.,Moon, B.J. and Harbeson, S. Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes. Journal of Medicinal Chemistry 27(4), 417-422 (1984). 4.Harbeson, S.L. and Rich, D.H. Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements. Journal of Medicinal Chemistry 32(6), 1378-1392 (1989). 5.Grembecka, J.,Mucha, A.,Cierpicki, T., et al. The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity. Journal of Medicinal Chemistry 46(13), 2641-2655 (2003). 6.Goto, Y.,Tanji, H.,Hattori, A., et al. Glutamine-181 is crucial in the enzymatic activity and substrate specificity of human endoplasmic-reticulum aminopeptidase-1. Biochemistry Journal 416(1), 109-116 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 511 |
| 分子式 | C21H38N4O8 • HCl |
| CAS号 | 100938-10-1 |
| 稳定性 | ≥ 2 years |
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