| 货号 | 15592-100mg |
| 描述 | Isoproterenol is a selective β-adrenoceptor agonist that shows high affinity for β1, β2, and β3(Ki = 224, 458, and 1,570 nM, respectively).1,2 Low concentrations of isoproterenol are sufficient to inhibit contractions in isolated field stimulated rat vas deferens (EC50 = 45.6 nM).3 Through its effects on β-adrenoceptor, isoproterenol increases cAMP levels and can activate protein kinase A and ERK1/2.4,5,6,2 |
| 别名 | Isoprenaline;NSC 37745;NSC 89747; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hoffmann, C.,Leitz, M.R.,Oberdorf-Maass, S., et al. Comparative pharmacology of human β-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedebergs Arch. Pharmacol. 369(2), 151-159 (2004). 2.Soriano-Ursúa, M.A.,McNaught-Flores, D.A.,Nieto-Alamilla, G., et al. Cell-based and in-silico studies on the high intrinsic activity of two boron-containing salbutamol derivatives at the human β2-adrenoceptor. Bioorganic & Medicinal Chemistry 20(2), 933-941 (2012). 3.Lotti, V.J.,Cerino, D. and Kling, P. Characterization of the adrenoreceptor activities of isoprenaline in the field stimulated rat vas deferens: Selective supersensitivity to β2-mediated responses following reserpine treatment. J.Auton.Pharmacol. 2(3), 169-174 (1982). 4.Jones, L.R.,Maddock, S.W. and Besch, H.R., Jr. Unmasking effect of alamethicin on the (Na+,K+)-ATPase, β-adrenergic receptor-coupled adenylate cyclase, and cAMP-dependent protein kinase activities of cardiac sarcolemmal vesicles. The Journal of Biological Chemisty 255(20), 9971-9980 (1980). 5.Gao, Y. and Raj, J.U. Effects of SQ 22536, an adenylyl cyclase inhibitor, on isoproterenol-induced cyclic AMP elevation and relaxation in newborn ovine pulmonary veins. European Journal of Pharmacology 436, 227-233 (2002). 6.Schmitt, J.M. and Stork, P.J.S. β2-adrenergic receptor activates extracellular regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf. The Journal of Biological Chemisty 275(33), 25342-25350 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 247.7 |
| 分子式 | C11H17NO3 • HCl |
| CAS号 | 51-30-9 |
| 稳定性 | ≥ 2 years |
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