ALK5 Inhibitor II (hydrochloride)
货号：
15526-1mg 基本售价：
364.0 元 规格：
1 mg
产品信息
概述| 货号 | 15526-1mg |
| 描述 | ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively).1 This inhibitor demonstrated less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3.1 At 25 μM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2via inhibition of the TGF-β signaling pathway and induction of Nanogtranscription.2 This product is a hydrochloride form of the compound. A non-hydrochloride version of ALK5 inhibitor II (Item No. 14794) is also available. |
| 别名 | E 616452;RepSox;SJN 2511; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gellibert, F.,Wollven, J.,Fouchet, M.H., et al. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-β type I receptor inhibitors. Journal of Medicinal Chemistry 47(18), 4494-4506 (2004).
2.Ichida, J.K.,Blanchard, J.,Lam, K., et al. A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog. Cell Stem Cell 5(5), 491-503 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 323.8 |
| 分子式 | C17H13N5 • HCl |
| 稳定性 | ≥ 2 years |
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