Rasagiline
货号：
14917-10mg 基本售价：
364.0 元 规格：
10 mg
产品信息
概述| 货号 | 14917-10mg |
| 描述 | Rasagiline is a selective and irreversible propargylamine inhibitor of monoamine oxidase (MAO) B (IC50s = 4.43 and 412 nM for MAO-B and MAO-A, respectively) that has been used to increase the availability of dopamine at striatal receptors as a strategy to treat Parkinson’s disease.1,2 Rasagiline is metabolized by hepatic cytochrome P450 (CYP)-1A2 to the neuroprotective compound aminoindan.2 In PC-12 and neuroblastoma SH-SY5Y cells, rasagiline exhibits neuroprotective and antiapoptotic activity against ischemia and several neurotoxins, including SIN-1, MPTP, 6-hydroxydopamine, and N-methyl-(R)-salsolinol.3 |
| 别名 | Azilect®; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Youdim, M.B.H.,Gross, A. and Finberg, J.P. Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. British Journal of Pharmacology 132(2), 500-506 (2001).
2.Finberg, J.P. Pharmacology of rasagiline, a new MAO-B inhibitor drug for the treatment of Parkinson’s disease with neuroprotective potential. Rambam Maimonides Med.J. 1(1), e0003 (2010).
3.Youdim, M.B.H. and Weinstock, M. Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R) aminoindan-5-YL)-ethyl methyl carbamate]. Cell Mol.Neurobiol. 21(6), 555-573 (2001).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 171.2 |
| 分子式 | C12H13N |
| CAS号 | 136236-51-6 |
| 稳定性 | ≥ 1 year |
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