Salubrinal
货号：
14735-1mg 基本售价：
364.0 元 规格：
1 mg
产品信息
概述| 货号 | 14735-1mg |
| 描述 | Salubrinal is a selective phosphatase inhibitor that prevents dephosphorylation of eukaryotic translation initiation factor 2 subunit α (eIF2α), protecting PC12 cells from endoplasmic reticulum stress-mediated apoptosis (EC50 = 15 μM).1,2 It appears to block the action of protein phosphatase 1 (PP1) on eIF2α although it does not mimic calyculin A, another PP1-selective inhibitor, in toxicity or phosphorylation pattern.1 Salubrinal also prevents replication of herpes virus (IC50 = 3 μM), by inhibiting dephosphorylation of eIF2α.1 As eIF2α has a role in bone formation, salubrinal is being studied for its effects in osteoporosis.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Boyce, M.,Bryant, K.F.,Jousse, C., et al. A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 307(5711), 935-939 (2005).
2.Long, K.,Boyce, M.,Lin, H., et al. Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorganic & Medicinal Chemistry Letters 15(17), 3849-3852 (2005).
3.Yokota, H.,Hamamura, K.,Chen, A., et al. Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells. BMC Musculoskeletal Disorders 14, 197 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 479.8 |
| 分子式 | C21H17Cl3N4OS |
| CAS号 | 405060-95-9 |
| 稳定性 | ≥ 2 years |
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