5-Fluorouracil
货号：
14416-5g 基本售价：
364.0 元 规格：
5 g
产品信息
概述| 货号 | 14416-5g |
| 描述 | 5-Fluorouracil (5-FU) is a pyrimadine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-FU exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis.1 5-FU has been widely used to treat many gastrointestinal tract adenocarcinomas.2 However, its clinical application is greatly limited due to drug resistance.3 |
| 别名 | 5-FU;NSC 19893;Ro 2-9757;U-8953; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Miwa, M.,Ura, M.,Nishida, M., et al. Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue. European Journal of Cancer 34(8), 1274-1281 (1998).
2.Wyatt, M.D. and Wilson, D.M., III. Participation of DNA repair in the response to 5-fluorouracil. Cell Mol.Life Sci. 66(5), 788-799 (2009).
3.Zhang, N.,Yin, Y.,Xu, S.J., et al. 5-Fluorouracil: Mechanisms of resistance and reversal strategies. Molecules 13(8), 1551-1569 (2008).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 130.1 |
| 分子式 | C4H3FN2O2 |
| CAS号 | 51-21-8 |
| 稳定性 | ≥ 2 years |
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