| 货号 | 13510-500ug |
| 描述 | 11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1. Early reports show that it is a selective agonist for the EP2 receptor but effective at much higher concentrations than PGE2.1,2 However, later studies show that it is a non-selective agonist of EP receptors and stimulates cAMP release in Jurkat cells with an EC50 of 0.25 µM.3 11-deoxy PGE1 also exhibits vasodepressor and bronchodilator responses in guinea pigs.4 11-deoxy PGE1 exhibits selectively for the mouse EP3 receptor and is essentially equipotent to PGE1 at this receptor subtype. The Ki values for binding to the mouse EP1, EP2, EP3, and EP4 receptors are 600, 45, 1.1, and 23 nM, respectively.5 |
| 别名 | 11-deoxy PGE1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dong, Y.J.,Jones, R.L., and Wilson, N.H. Prostaglandin E receptor subtypes in smooth muscle: Agonist activities of stable prostacyclin analogues. British Journal of Pharmacology 87, 97-107 (1986). 2.Chen, J., and Woodward, D.F. Prostanoid-induced relaxation of precontracted cat ciliary muscle is mediated by EP2 and DP receptors. Investigative Ophthalmology & Visual Science 33, 3195-3201 (1992). 3.De Vries, G.W.,Guarino, P.,McLaughlin, A., et al. An EP receptor with a novel pharmacological profile in the T-cell line Jurkat. British Journal of Pharmacology 115, 1231-1234 (1995). 4.Hall, D.W.R., and Jaitly, K.D. Structure-activity relationships in a series of 11-deoxy prostaglandins. Prostaglandins 11, 573-587 (1976). 5.Kiriyama, M.,Ushikubi, F.,Kobayashi, T., et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. British Journal of Pharmacology 122, 217-224 (1997). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥96% |
| 计算分子量 | 338.5 |
| 分子式 | C20H34O4 |
| CAS号 | 37786-00-8 |
| 稳定性 | ≥ 2 years |
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