Tenovin-1
货号：
13085-5mg 基本售价：
364.0 元 规格：
5 mg
产品信息
概述| 货号 | 13085-5mg |
| 描述 | Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 µM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells.1 Functioning upstream of p53, tenovin-1 acts by inhibiting the deacetylase activity of purified human SIRT1 and SIRT2, members of NAD+-dependent class III histone deacetylases that belong to the sirtuin family.1 While tenovin-1 demonstrates low genotoxicity, the compound has poor water solubility, which limits its uses in vivo. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lain, S.,Hollick, J.J.,Campbell, J., et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13, 454-463 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 369.5 |
| 分子式 | C20H23N3O2S |
| CAS号 | 380315-80-0 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
