| 货号 | 10272-250ug |
| 描述 | Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells with an IC50 value of ~0.5 µM.1 Originally, prostratin was isolated from plant sources including P. prostrata,E. cornigera, and H. nutans.2 The effects of prostratin are mediated through activation of NF-κB via protein kinase C and by downregulation of HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5.3,4,5 |
| 别名 | 13-O-Acetylphorbol;NSC 623310;SA 101A; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bedoya, L.M.,Márquez, N.,Martínez, N., et al. SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vivo. Biochemical Pharmacology 77, 965-978 (2009). 2.Wender, P.A.,Kee, J.M. and Warrington, J.M. Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV. Science 320, 649-652 (2008). 3.Williams, S.A.,Chen, L.F.,Kwon, H., et al. Prostratin antagonizes HIV latency by activating NF- k B. The Journal of Biological Chemisty 279(40), 42008-42017 (2004). 4.Biancotto, A.,Grivel, J.C.,Gondois-Rey, F., et al. Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue. Journal of Virology 78(19), 10507-10515 (2004). 5.Hezareh, M.,Moukil, M.A.,Szanto, I., et al. Mechanisms of HIV receptor and co-receptor down-regulation by prostratin: Role of conventional and novel PKC isoforms. Antiviral Chemistry & Chemotherapy 15, 207-222 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 390.5 |
| 分子式 | C22H30O6 |
| CAS号 | 60857-08-1 |
| 稳定性 | ≥ 1 year |
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