HE-3235
货号：
9002769-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 9002769-1mg |
| 描述 | HE-3235 is a synthetic adrenal hormone, an androstanediol analog, that acts as an androgen receptor antagonist.1 In an androgen receptor-dependent manner, it downregulates anti-apoptotic genes, while increasing the expression of pro-apoptotic genes, thus stimulating apoptosis.1 HE-3235 has been shown to inhibit androstenediol-dependent LNCaP cell tumor growth both in vitro(IC50 = 6 nM) and in xenograft models in vivo.1,2 |
| 别名 | Apoptone;17α-Ethynyl-5α-androstane-3α,17ß-diol; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Trauger, R.,Corey, E.,Bell, D., et al. Inhibition of androstenediol-dependent LNCaP tumour growth by 17α-ethynyl-5α-androstane-3α, 17β-diol (HE3235). Br.J.Cancer. 100(7), 1068-1072 (2009).
2.Koreckij, T.D.,Trauger, R.J.,Montgomery, R.B., et al. HE3235 inhibits growth of castration-resistant prostate cancer. Neoplasia 11(11), 1216-1225 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 316.5 |
| 分子式 | C21H32O2 |
| CAS号 | 183387-50-0 |
| 稳定性 | ≥ 2 years |
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