| 货号 | 9002196-5g |
| 描述 | Alloxan is a toxin that selectively eliminates pancreatic β-cells in mice, rats, and certain other animals, and is used to model type 1 diabetes in humans.1 Reduction of alloxan within β-cells precedes the generation of reactive oxygen species, which in turn contribute to β-cell death.2 The dose of alloxan needed to destroy beta cells, and thus induce diabetes, depends on the animal species, route of administration, and nutritional status.2,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dunn, J.S.,Duffy, E.,Gilmour, M.K., et al. Further observations on the effects of alloxan on the pancreatic islets. Journal of Physiology 103(2), 233-243 (1944). 2.Szkudelski, T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol.Res. 50, 536-546 (2001). 3.Eizirik, D.L.,Pipeleers, D.G.,Ling, Z., et al. Major species differences between humans and rodents in the susceptibility to pancreatic β-cell injury. Proceedings of the National Academy of Sciences of the United States of America 91(20), 9253-9256 (1994). 4.Tyberg, B.,Andersson, A., and Borg, L.A. Species differences in susceptibility of transplanted and cultured pancreatic islets to the β-cell toxin alloxan. General and Comparative Endocrinology 122, 238-251 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 160.1 |
| 分子式 | C4H2N2O4 • H2O |
| CAS号 | 125952 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |