| 货号 | 9001820-5mg |
| 描述 | Levetiracetam is a second generation antiepileptic compound used to prevent convulsions in a variety of settings.1,2 It binds the synaptic vesicle protein SV2A (pIC50 = 5.7), presumably altering vesicle exocytosis.3 Presumably through this mechanism, levetiracetam alters the metabolism and turnover of γ-aminobutyric acid in the brain.4 It can also suppress the processing of amyloid beta (Aβ) precursor protein to Aβ40 and Aβ42, an important process in Alzheimer’s disease.5 Levetiracetam has been reported to elicit diverse psychotropic effects.6 |
| 别名 | Keppra®;UCB-L 059; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Reimers, A., and Brodtkorb, E. Second-generation antiepileptic drugs and pregnancy: A guide for clinicians. Expert Rev.Neurother. 12(6), 707-717 (2012). 2.Löscher, W., and Brandt, C. Prevention or modification of epileptogenesis after brain insults: Experimental approaches and translational research. Pharmacological Reviews 62(4), 668-700 (2010). 3.Lynch, B.A.,Lamberg, N.,Nocka, K., et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proceedings of the National Academy of Sciences of the United States of America 101(26), 9861-9866 (2004). 4.Löscher, W.,Hönack, D., and Bloms-Funke, P. The novel antiepileptic drug levetiracetam ( ucb L059) induces alterations in GABA metabolism and turnover in discrete areas of rat brain and reduces neuronal activity in substantia nigra pars reticulata. Brain Research 735(2), 208-216 (1996). 5.Rhinn, H.,Fujita, R.,Qiang, L., et al. Integrative genomics identifies APOE .epilson.4 effectors in Alzheimer’s disease. Nature 500(7460), 45-50 (2013). 6.Piedad, J.,Rickards, H.,Besag, F.M.C., et al. Beneficial and adverse psychotropic effects of antiepileptic drugs in patients with epilepsy. CNS Drugs 26(4), 319-335 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 170.2 |
| 分子式 | C8H14N2O2 |
| CAS号 | 102767-28-2 |
| 稳定性 | ≥ 2 years |
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