| 货号 | 9001730-500ug |
| 描述 | Prostaglandin E1(PGE1) is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid.1 Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 value of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.2,3PGE1 is used to treat male erectile dysfunction and to maintain ductus arteriosus patency in infants.4,5PGE1 ethyl ester is an esterified form of the free acid which may be more amenable for certain applications. |
| 别名 | Alprostadil ethyl ester;PGE1 ethyl ester; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Cawello, W.,Schweer, H.,Dietrich, B., et al. Pharmacokinetics of prostaglandin E1 and its main metabolites after intracavernous injection and short-term infusion of prostaglandin E1 in patients with erectile dysfunction. Journal of Urology 158, 1403-1407 (1997). 2.Kobzar, G.,Mardla, V.,Järving, I., et al. Antiaggregating potency of E-type prostaglandins in human and rabbit platelets. Proceedings of the Estonian Academy of Sciences.Chemistry 40, 179-180 (1991). 3.Okada, F.,Nukada, T.,Yamauchi, Y., et al. The hypotensive effect of prostaglandin E1 on hypertensive cases of various types. Prostaglandins 7, 99-106 (1974). 4.Padma-Nathan, H.,Hellstrom, W.J.G.,Kaiser, F.E., et al. Treatment of men with erectile dysfunction with transurethral alprostadil. New England Journal of Medicine 336, 1-7 (1997). 5.Olley, P.M., and Coceani, F. Prostaglandins and the ductus arteriosus. Annual Reviews of Medicine 32, 375-3785 (1981). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 382.5 |
| 分子式 | C22H38O5 |
| CAS号 | 35900-16-4 |
| 稳定性 | ≥ 2 years |
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