| 货号 | 9000571-1mg |
| 描述 | Glatiramer (acetate) is a mixture of synthetic polypeptides composed of four amino acids found in myelin basic protein (MBP): L-Alanine, L-glutamic acid, L-lysine, and L-tyrosine. It prevents MBP from binding to MHC class II molecules in the periphery and induces the production of immunomodulatory molecules considered to be anti-inflammatory.1 It also increases proliferation of oligodendrocyte and neuronal precursor cells in the central nervous system of mice.2,3 Formulations containing glatiramer (acetate) are used to treat patients with multiple sclerosis, particularly the relapsing-remitting type.4 |
| 别名 | Copolymer 1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Aharoni, R. The mechanism of action of glatiramer acetate in multiple sclerosis and beyond. Autoimmun. Rev. 12(5), 543-553 (2013). 2.Skihar, V.,Silva, C.,Choinacki, A., et al. Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate. Proc. Natl. Acad. Sci. USA 106(42), 17992-17997 (2009). 3.Aharoni, R.,Arnon, R., and Eilam, R. Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitis. J. Neurosci. 25(36), 8217-8228 (2005). 4.Ziemssen, T.,Ashtamker, N.,Rubinchik, S., et al. Long-term safety and tolerability of glatiramer acetate 20 mg/ml in the treatment of relapsing forms of multiple sclerosis. Expert Opin. Drug Discov. 16(2), 248-255 (2017). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 623.7 |
| 分子式 | C9H11NO3 • C6H14N2O2 • C5H9NO4 • C3H7NO2 • C2H4O2 |
| CAS号 | 147245-92-9 |
| 稳定性 | ≥ 2 years |
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