T0901317
货号：
71810-10mg 基本售价：
350.0 元 规格：
10 mg
产品信息
概述| 货号 | 71810-10mg |
| 描述 | The Liver X Receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and selective agonist for both LXRα and LXRβ, with an EC50 of about 50 nM.1 T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Repa, J.J.,Turley, S.D.,Lobaccaro, J.M.A., et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289, 1524-1529 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 481.3 |
| 分子式 | C17H12F9NO3S |
| CAS号 | 293754-55-9 |
| 稳定性 | ≥ 1 year |
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