| 货号 | 70255-100mg |
| 描述 | (R)-Flurbiprofen is a member of the 2-aryl propionic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Only a small amount (<5%) of (R)-enantiomer is converted to the (S)-enantiomer in rats and humans; therefore, the biological effects are specific to each enantiomer.1 Although inactive as an inhibitor of cyclooxygenase (COX), this enantiomer reduces inflammation through inhibition of NF-κB and AP-1 activation.2 (R)-Flurbiprofen has also been shown to suppress prostate tumor cells by inducing p75NTR protein expression.3 (R)-Flurbiprofen inhibits the enzyme γ-secretase thereby preventing the formation of the amyloid β peptide (Aβ42) from amyloid β precursor protein (APP).4 Before being dropped as a drug candidate, (R)-flurbiprofen advanced to Phase III clinical trials, the first drug candidate to advance to late stage trials for the treatment of mild Alzheimer’s disease. |
| 别名 | E-7869;Flurizan;Tarenflurbil; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brune, K.,Beck, W.S.,Geisslinger, G., et al. Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition. Experientia 47, 257-261 (1991). 2.Tegeder, I.,Niederberger, E.,Israr, E., et al. Inhibition of NF- k B and AP-1 activation by R- and S-flurbiprofen1,2. The FASEB Journal 15, 595-597 (2001). 3.Quann, E.J.,Khwaja, F.,Zavitz, K.H., et al. The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells. Cancer Research 67(7), 3254-3262 (2007). 4.Kukar, T.L.,Ladd, T.B.,Bann, M.A., et al. Substrate-targeting g -secretase modulators. Nature 453, 925-929 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥99% |
| 计算分子量 | 244.3 |
| 分子式 | C15H13FO2 |
| CAS号 | 51543-40-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |