| 货号 | 63280-50mg |
| 描述 | Miltefosine is an inhibitor of CTP:phosphocholine cytidylyl transferase and has antimetastatic properties.1,2,3 At concentrations of 3 and 25 µM, miltefosine inhibits proliferation of HaCaT cells (immortalized human keratinocyte cell line) by 50% and 94%, respectively.4 The mechanism of action of miltefosine is not well established, but the antiproliferative effect may be mediated by an increase in cellular ceramide which results in apoptosis. Treatment of cells with 25 µM miltefosine results in a 53% increase in ceramide concentration relative to control.4 Miltefosine is more than 90% effective in eradicating visceral infections of Leishmania species (kala azar), although the mechanism of this antiprotozoal activity is also poorly understood.5 |
| 别名 | HePC; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Geilen, C.C.,Wieder, T., and Reutter, W. Hexadecylphosphocholine inhibits translocation of CTP: Choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cells. The Journal of Biological Chemisty 267, 6719-6724 (1992). 2.Wieder, T.,Geilen, C.C., and Reutter, W. Antagonism of phorbol-ester-stimulated phosphatidylcholine biosynthesis by the phospholipid analogue hexadecylphosphocholine. Biochemistry Journal 291, 561-567 (1993). 3.Geilen, C.C.,Haase, R.,Buchner, K., et al. The phospholipid analogue, hexadecylphosphocholine, inhibits protein kinase C in vitro and antagonises phorbol ester-stimulated cell proliferation. European Journal of Cancer 27, 1650-1653 (1991). 4.Wieder, T.,Orfanos, C.E., and Geilen, C.C. Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine. The Journal of Biological Chemisty 273, 11025-11031 (1998). 5.Sundar, S.,Jha, T.K.,Thakur, C.P., et al. Oral miltefosine for indian visceral leishmaniasis. New England Journal of Medicine 347 (22), 1739-1746 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 407.6 |
| 分子式 | C21H46NO4P |
| CAS号 | 58066-85-6 |
| 稳定性 | ≥ 1 year |
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