| 货号 | 53400-25ug |
| 描述 | Leukotoxin is the 9(10) epoxide of linoleic acid, generated by neutrophils during the oxidative burst.1,2,3 This unstable compound is rapidly degraded by epoxide hydrolases to form the diol, (±)9(10)-DiHOME.4 Mitochondrial dysfunction, vasodilation, and apoptosis are features of leukotoxin toxicity. In renal proximal tubular cells, the diol hydrolysis products of leukotoxin, such as (±)9(10)-DiHOME, have been directly implicated as the cytotoxic agent responsible for cell death.5 |
| 别名 | Leukotoxin diol; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hayakawa, M.,Sugiyama, S.,Takamura, T., et al. Neutrophils biosynthesize leukotoxin, 9,10-epoxy-12-octadecenoate. Biochemical and Biophysical Research Communications 137, 424-430 (1986). 2.Ishizaki, T.,Takahashi, H.,Ozawa, T., et al. Leukotoxin, 9,10-epoxy-12-octadecenoate causes pulmonary vasodilation in rats. Journal of the American Physiological Society 1040, L123-L128 (1995). 3.Ozawa, T.,Hayakawa, M.,Takamura, T., et al. Biosynthesis of leukotoxin, 9,10-epoxy-12 octadecenoate, by leukocytes in lung lavages of rat after exposure to hyperoxia. Biochemical and Biophysical Research Communications 134, 1071-1078 (1986). 4.Greene, J.F.,Williamson, K.C.,Newman, J.W., et al. Metabolism of monoepoxides of methyl linoleate: Bioactivation and detoxification. Archives of Biochemistry and Biophysics 376, 420-432 (2000). 5.Moran, J.H.,Weise, R.,Schnellmann, R.G., et al. Cytotoxicity of linoleic acid diols to renal proximal tubular cells. Toxicology and Applied Pharmacology 146, 53-59 (1997). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 314.5 |
| 分子式 | C18H34O4 |
| CAS号 | 263399-34-4 |
| 稳定性 | ≥ 1 year |
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