MONNA
货号：
21917-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21917-1mg |
| 描述 | MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 µM in Xenopus oocytes), a calcium-activated chloride channel (CaCC).1 It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 µM. MONNA (10 µM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride.2 It also hyperpolarizes isolated rat mesenteric arteries under resting conditions. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Oh, S.J.,Hwang, S.J.,Jung, J.E., et al. MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1. Mol. Pharmacol. 84(5), 726-735 (2013).
2.Boedtkjer, D.M.B.,Kim, S.,Jensen, A.B., et al. New selective inhibitors of calcium-activated chloride channels - T16Ainh-A01, CaCCinh-A01 and MONNA - what do they inhibit? Br. J. Pharmacol. 172(16), 4158-4172 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 338.3 |
| 分子式 | C18H14N2O5 |
| CAS号 | 1572936-83-4 |
| 稳定性 | ≥ 2 years |
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