| 货号 | 21895-1mg |
| 描述 | JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel. Activation of P2X receptors by BzATP (Item No. 15577) induces calcium flux, which is reduced by JNJ-47965567 in 1321N1 cells transfected with recombinant P2X7 human, macaque, dog, rat, or mouse protein with pIC50s of 8.3, 8.6, 8.5, 7.2, or 7.5, respectively.1 JNJ-47965567 suppresses neonatal hypoxia-induced seizures in mice and has some anticonvulsant properties in rats.2,3 It also reduces spontaneous seizures in epileptic mice even after treatment is stopped.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bhattacharya, A.,Wang, Q.,Ao, H., et al. Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567. Br. J. Pharmacol. 170(3), 624-640 (2013). 2.Rodriguez-Alvarez, N.,Jimenez-Mateos, E.M.,Engel, T., et al. Effects of P2X7 receptor antagonists on hypoxia-induced neonatal seizures in mice. Neuropharmacology 116(2017), 351-363 (2017). 3.Fischer, W.H.,Franke, H.,Krügel, U., et al. Critical evaluation of P2X7 receptor antagonists in selected seizure models. PLoS One 11(6), e0156468 (2016). 4.Jimenez-Pacheco, A.,Diaz-Hernandez, M.,Arribas-Blázquez, M., et al. Transient P2X7 receptor antagonism produces lasting reductions in spontaneous seizures and gliosis in experimental temporal lobe epilepsy. J. Neurosci. 36(22), 5920-5932 (2016). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 488.6 |
| 分子式 | C28H32N4O2S |
| CAS号 | 1428327-31-4 |
| 稳定性 | ≥ 2 years |
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