OSMI-1
货号：
21894-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21894-1mg |
| 描述 | OSMI-1 is a quinolinone-6-sulfonamide that inhibits O-GlcNAc transferase (OGT; IC50 = 2.7 μM) in vitro.1 It is cell permeable and inhibits global O-GlcNAcylation in a dose-dependent manner in CHO cells. OSMI-1 induces a mass shift of nucleoporin62 (Nup62) that corresponds to the loss of O-GlcNAc residues and decreases levels of cellular O-GlcNAcase (OGA). OSMI-1 (50 μM) also causes a 50% decrease in CHO cell viability after 24 hours. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ortiz-Meoz, R.F.,Jiang, J.,Lazarus, M.B., et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 10(6), 1392-1397 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 563.6 |
| 分子式 | C28H25N3O6S2 |
| CAS号 | 1681056-61-0 |
| 稳定性 | ≥ 2 years |
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