Picrotin
货号：
21870-25mg 基本售价：
350.0 元 规格：
25 mg
产品信息
概述| 货号 | 21870-25mg |
| 描述 | Picrotin is a natural picrotoxane that antagonizes glycine receptors (GlyRs; IC50s = 57 and 117 µM for α1 and α2 homodimeric GlyRs, respectively).1,2 It also inhibits α3 homodimeric GlyRs.3 Picrotin is inactive in inhibiting γ-aminobutyric acid (GABA) type A and type C receptors. Picrotin occurs in the natural plant-derived poison picrotoxin (Item No. 20771), equimolar with picrotoxinin. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lynch, J.W.,Rajendra, S.,Barry, P.H., et al. Mutations affecting the glycine receptor agonist transduction mechanism convert the competitive antagonist, picrotoxin, into an allosteric potentiator. J. Biol. Chem. 270(23), 13799-13806 (1995).
2.Wang, D.-S.,Buckinx, R.,Lecorronc, H., et al. Mechanisms for picrotoxinin and picrotin blocks of α2 homomeric glycine receptors. J. Biol. Chem. 282(22), 16016-16035 (2007).
3.Yang, Z.,Cromer, B.A.,Harvey, R.J., et al. A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J. Neurochem. 103(2), 580-589 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 310.3 |
| 分子式 | C15H18O7 |
| CAS号 | 21416-53-5 |
| 稳定性 | ≥ 2 years |
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