JNJ-42756493
货号：
21813-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21813-1mg |
| 描述 | JNJ-42756493 is an orally bioavailable inhibitor of fibroblast growth factor receptor (FGFR) with IC50 values of 1.2, 2.5, 3, and 5.7 nM for FGFR1-4, respectively, using isolated recombinant FGFR kinases.1 It is selective for FGFR over the VEGF receptor 2 (IC50 = 36.8 nM). It inhibits proliferation in Ba/F3 cells expressing FGFR subtypes with IC50 values of 22.1, 13.2, and 25 nM for FGFR1, 3, and 4, respectively. It inhibits FGFR activity in non-tumor and tumor cell lines, as well as in xenograft models.1 Formulations containing JNJ-42756493 are in Phase II clinical trials for patients with various cancers. |
| 别名 | Erdafitinib; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Perera, T.P.S.,Jovcheva, E.,Mevellec, L., et al. Discovery and pharmacological characterization of JNJ-42756493 (erdafitinib), a functionally selective small molecule FGFR family inhibitor. Mol. Cancer Ther. (2017).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 446.5 |
| 分子式 | C25H30N6O2 |
| CAS号 | 1346242-81-6 |
| 稳定性 | ≥ 2 years |
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