| 货号 | 21746-10mg |
| 描述 | 3-Propylxanthine is a xanthine derivative that antagonizes adenosine receptors (Kis = 44, 32, and 6.3 µM for A1, A2A, and A2B, respectively) and cAMP phosphodiesterase (Ki = 42 µM).1,2,3 Through these actions, 3-propylxanthine induces smooth muscle relaxation, blocks smooth muscle contraction and VEGF secretion driven by adenosine receptor agonists, and reduces bronchial hyperresponsiveness.4,5,2 |
| 别名 | D 4028;Enprofylline; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Linden, J.,Thai, T.,Figler, H., et al. Characterization of human A2B adenosine receptors: Radioligand binding, western blotting, and coupling to Gq in human embryonic kidney 293 cells and HMC-1 mast cells. Molecular Pharmacology 56(4), 705-713 (1999). 2.Ogawa, K.,Takagi, K., and Satake, T. Mechanism of xanthine-induced relaxation of guinea-pig isolated trachealis muscle. Br. J. Pharmacol. 97(2), 542-546 (1989). 3.Schwabe, U.,Ukena, D., and Lohse, M.J. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn-Schmiedebergs Arch.Pharmacol. 330, 212-221 (1985). 4.Høier, B.,Olsen, K.M.,Nyberg, M., et al. Contraction-induced secretion of VEGF from skeletal muscle cells is mediated by adenosine. Am. J. Physiol. Heart. Circ. Physiol. 299(3), H857-H862 (2010). 5.Koëter, G.H.,Kraan, J.,Boorsma, M., et al. Effect of theophylline and enprofylline on bronchial hyperresponsiveness. Thorax 44(12), 1022-1026 (1989). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 194.2 |
| 分子式 | C8H10N4O2 |
| CAS号 | 41078-02-8 |
| 稳定性 | ≥ 2 years |
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