| 货号 | 21745-25g |
| 描述 | Theobromine is a purine alkaloid that is an adenosine receptor antagonist (IC50 = 210-280 µM for [3H]cyclohexyladenosine binding in rat brain).1 It is found in the cacao bean and in chocolate products. In vitro, it inhibits adipogenesis at the differentiation stage through an MAPK signaling mechanism.2 It also activates sirtuin 1 (SIRT1) in a rat model of diabetes mellitus, leading to positive effects.3 At commonly ingested doses, it does not appear to have any behavioral effects.4,5 Theobromine is toxic to dogs with an LD50 value of 250-500 mg/kg.6 |
| 别名 | Diurobromine;NSC 5039;SC-15090; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Daly, J.W.,Butts-Lamb, P., and Padgett, W. Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines. Cell. Mol. Neurobiol. 3(1), 69-80 (1983). 2.Jang, Y.J.,Koo, H.J.,Sohn, E.-H., et al. Theobromine inhibits differentiation of 3T3-L1 cells during the early stage of adipogenesis via AMPK and MAPK signaling pathways. Food Funct. 6(7), 2365-2374 (2015). 3.Papadimitriou, A.,Silva, K.C.,Peixoto, E.B.M.I., et al. Theobromine increases NAD⁺/Sirt-1 activity and protects the kidney under diabetic conditions. Am. J. Physiol. Renal Physiol. 308(3), D209-F225 (2015). 4.Snyder, S.H.,Katims, J.J.,Annau, Z., et al. Adenosine receptors and behavioral actions of methylxanthines. Proc. Natl. Acad. Sci. USA 78(5), 3260-3264 (1981). 5.Judelson, D.A.,Preston, A.G.,Miller, D.L., et al. Effects of theobromine and caffeine on mood and vigilance. J. Clin. Psychopharmacol. 33(4), 499-506 (2013). 6.Lawrence, L.P. Chocolate toxicosis. The 5-minute veterinary consult : Canine and feline (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 180.2 |
| 分子式 | C7H8N4O2 |
| CAS号 | 83-67-0 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |