| 货号 | 21698-100mg |
| 描述 | Glycoursodeoxycholic acid (GUDCA) is a glycine conjugate of ursodeoxycholic acid (UDCA; Item No. 15121) created during first-pass metabolism of UDCA.1 It is more hydrophilic than the unconjugated form. In a mouse model of colitis, daily oral administration of GUDCA (500 mg/kg/day) decreases the severity of symptoms and increases the amount of a bacterial species (A. muciniphila) commonly decreased in patients with inflammatory bowel disease (IBD).1 It has antioxidant effects in vitro in Barrett’s esophagus cells and primary cultured rat neurons.2,3 It also prevents astroglial cell death from exposure to unconjugated bilirubin, an in vitro model of neonatal hyperbilirubinemia, and reduces the levels of inflammatory cytokines in those astroglial cultures.4 |
| 别名 | GUDCA;Ursodeoxycholyl Glycine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Van den Bossche, L.,Hindryckx, P.,Devisscher, L., et al. Ursodeoxycholic acid and its taurine- or glycine-conjugated species reduce colitogenic dysbiosis and equally suppress experimental colitis in mice. Appl. Environ. Microbiol. 83(7), e02766-02716 (2017). 2.Goldman, A.,Condon, A.,Adler, E., et al. Protective effects of glycoursodeoxycholic acid in Barrett’s esophagus cells. Dis. Esophagus 23(2), 83-93 (2010). 3.Brito, M.A.,Lima, S.,Fernandes, A., et al. Bilirubin injury to neurons: Contribution of oxidative stress and rescue by glycoursodeoxycholic acid. Neurotoxicology 29(2), 259-269 (2008). 4.Fernandes, A.,Vaz, A.R.,Falcao, A.S., et al. Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin. J. Neuropathol. Exp. Neurol. 66(9), 789-798 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 449.6 |
| 分子式 | C26H43NO5 |
| CAS号 | 64480-66-6 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |