DG-051
货号：
21688-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21688-1mg |
| 描述 | DG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor (Kd = 25 nM; IC50 = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB4 (Item No. 20110).1 However, it also inhibits the aminopeptidase activity of LTA4H with IC50 values of 72 and 150 nM when tested using the substrates L-alanine p-nitroanaline and prolyl-glycyl-proline peptide (PGP; Item No. 11188), respectively, potentially leading to PGP accumulation in vivo.1,2 DG-051 does not show any inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sandanayaka, V.,Mamat, B.,Mishra, R.K., et al. Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J. Med. Chem. 53(2), 573-585 (2010).
2.Low, C.M.,Akthar, S.,Patel, D.F., et al. The development of novel LTA4H modulators to selectively target LTB4 generation. Sci. Rep. 7, 44449 (2017).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 426.3 |
| 分子式 | C21H24ClNO4 • HCl |
| CAS号 | 929915-58-2 |
| 稳定性 | ≥ 1 year |
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