BAY 12-17389
货号：
21660-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21660-1mg |
| 描述 | BAY 12-17389 is an inhibitor of monopolar spindle 1 (Mps1 or TTK; IC50 = 0.27 nM), a serine/threonine/tyrosine kinase involved in cell division.1 It is orally bioavailable and, through its effects on Mps1, inactivates the spindle assembly checkpoint, accelerates mitosis, and causes chromosomal misalignment and missegregation.1 BAY 12-17389 induces cell death in Mps1-overexpressing cancer cells and improves efficacy of paclitaxel (Item No. 10461) in tumor therapy.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wengner, A.M.,Siemeister, G.,Koppitz, M., et al. Novel Mps1 kinase inhibitors with potent antitumor activity. Mol. Cancer Ther. 15(4), 583-592 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 561.5 |
| 分子式 | C27H24F5N5O3 |
| CAS号 | 1554458-53-5 |
| 稳定性 | ≥ 2 years |
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