M8-B (hydrochloride)
货号：
21646-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21646-1mg |
| 描述 | M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin (Item No. 10137), or menthol in vitro(IC50s = 7.8, 26.9, and 64.3 nM, respectively).1 It displays no effect at other TRP channels. M8-B decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Almeida, M.C.,Hew-Butler, T.,Soriano, R.N., et al. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J. Neurosci. 32(6), 2086-2099 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 433 |
| 分子式 | C22H24N2O3S • HCl |
| CAS号 | 883976-12-3 |
| 稳定性 | ≥ 2 years |
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