Coenzyme B12
货号：
21571-25mg 基本售价：
350.0 元 规格：
25 mg
产品信息
概述| 货号 | 21571-25mg |
| 描述 | Coenzyme B12 (adenosylcobalamin; AdoCbl) is a biologically active form of vitamin B12 (Item No. 18425). It belongs to the corrinoid group of compounds, which contain a corrin macrocycle, and is produced only by certain bacteria and archaea.1 It is a cofactor for various enzymes including mutases, eliminases, aminomutases, and a reductase.2 These enzymes catalyze reactions that generate free radicals through release of the adenosyl group, allowing usually unreactive molecules to become reactive. Only one of these enzymes, methylmalonyl CoA mutase, is found in mammals, therefore, the other enzymes must be taken in through the diet. Genetic mutations in enzymes that synthesize AdoCbl lead to AdoCbl deficiency and methylmalonic aciduria.3 Formulations containing AdoCbl are used to treat patients with this disorder. |
| 别名 | Adenosylcobalamin;AdoCbl;Cobamamide;Dibenzcozamide;LM-176; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Moore, S.J.,Lawrence, A.D.,Biedendieck, R., et al. Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12). Proc. Natl. Acad. Sci. USA 110(37), 14906-14911 (2015).
2.Marsh, E.N.G., and Meléndez, G.D.R. Adenosylcobalamin enzymes: Theory and experiment begin to converge. Biochim Biophys. Acta. 1824(11), 1154-1164 (2012).
3.Watkins, D.N.,Rosenblatt, D.S., and Flower, B. Adenosylcobalamin deficiency. Inborn metabolic diseases: Diagnosis and treatment (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1579.6 |
| 分子式 | C72H100CoN18O17P |
| CAS号 | 13870-90-1 |
| 稳定性 | ≥ 2 years |
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